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The principal cytochrome P450 isoenzyme concerned appears for being CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. About 85% of an oral dose seems in the urine in just 24 hrs of administration, most given that the glucuronide conjugate, with tiny quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity information.Lamotrig